ΥΓΕΙΑ health
Maria Dalamagka academic profile
https://share.google/3jZOfBHvdnk5CHBOJ
https://medicinegr.blogspot.com/2024/10/httpsdoi.html
Multiple sclerosis an chronic demyelinating disease and anesthesia management
Zenodo
https://share.google/147BqZGOzuowdwi1p
Academia.edu
https://share.google/gHETsmJWjLeoYUtdL
Review Article
Magna Scientia Advanced Research and Reviews, 2025, 15(01), 180-184
Article DOI: 10.30574/msarr.2025.15.1.0124
Abstract:
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) and the most common chronic demyelinating disease affecting approximately 2.8 million people worldwide. Its high prevalence worldwide makes it probable for an anesthesia professional to take care of a patient diagnosed with MS at some point during their career. MS is an immune-mediated disease characterized by inflammation, demyelination, and axonal damage in the central nervous system. The course of MS is characterized by exacerbations and remissions at unpredictable intervals over a period of several years. Progression of disability due to MS is highly variable among patients. General, epidural, and spinal anesthesia are generally deemed safe when used in patients with the disease. General anesthesia is the most common anesthetic technique used. There is more controversy surrounding spinal anesthesia, but it seems spinal anesthesia can be administered safely without any additional increased risk of disease relapse. The purpose of the preoperative assessment is to ensure the patient undergoes a safe and adequate anaesthetic experience by selecting the most suitable type of anaesthesia. This assessment must include the full documentation of the neurological deficits detailed by the neurologist in charge of the patient. The use of an established score such as the “Expanded Disability Status Scale” score or “EDSS” score should also be used in order to evaluate the degree of disability. Besides neurological data, the preoperative assessment conducted by the anaesthesiologist should also document any respiratory, cardiac, renal, hepatic, autonomic or any other medical comorbidities. There is a lack of published guidelines on the management of patients with multiple sclerosis (MS) undergoing procedures that require anaesthesia. The anaesthetic management covers preoperative assessment, choice of anaesthetic techniques and agents, side-effects of drugs used during anaesthesia and their potential impact on the disease evolution and drug interactions. The choice of the anaesthetic technique used should be made after careful assessment of the risks and benefits for each specific patient and his preference must also be considered. The association of general anaesthesia and epidural with low concentrations of local anaesthetic are considered safe. Post-operative MS relapses are not affected by the choice of the anaesthetic technique, and that all techniques, including general anaesthesia, may be safely used.
_________________________________________________
Autoimmune diseases in children and anesthesia
Semantic Scholar
https://share.google/XnkrxoFSTcreF06st
ResearchGate
https://share.google/WuUKJJHGtGxvaWcdx
Review Article
Magna Scientia Advanced Biology and Pharmacy, 2025, 14(01), 045-052
Article DOI: 10.30574/msabp.2025.14.1.0022
Abstract:
Autoimmune diseases in children may be linked to genetic, environmental, and hormonal factors. It’s estimated that 5% of children worldwide have at least one autoimmune condition, with many experiencing multiple autoimmune challenges. Around 80 autoimmune diseases are present. However, autoimmune diseases in children are rare. When they occur they can be challenging to diagnose and difficult to treat. Advances in our knowledge of the immune system are uncovering connections between inflammation and many different diseases. All autoimmune diseases have relapsing and remitting tendencies. Autoimmune diseases can affect almost any part of the body, though they often target connective tissues (skin, muscle and joints). Symptoms can range from fatigue and mild rashes to rare, serious side effects, like seizures. Diagnosis can be difficult, because many symptoms tend to come and go and are frequently nonspecific. They occur in different kinds of autoimmune diseases as well as other types of illnesses, like infection and cancer. Autoimmune diseases occur most often in females by a 3-to-1 margin over males. Organ-specific disorders (also called localized) focus on one organ or a specific type of tissue: Addison's disease affects the adrenal glands; Autoimmune hepatitis affects the liver; Crohn's disease affects the gastrointestinal tract; Multiple sclerosis (MS) affects the central nervous system; Type 1 diabetes affects the pancreas; Ulcerative colitis affects the gastrointestinal tract. Non-organ-specific disorders (also called systemic) cause problems throughout the body: Juvenile dermatomyositis affects the skin and muscles; Juvenile idiopathic arthritis affects the joints and sometimes the skin and lungs; Lupus affects the joints, skin, liver, kidneys, heart, brain, and other organs; Scleroderma affects the skin, joints, intestine, and sometimes the lungs. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are rare neurobehavioral disorders in children. Affected children may have a diverse array of perioperative manifestations including compulsive behavior, agitation, and abnormal movements. Intravenous anesthetics have anti-inflammatory properties, which in most septic cases are useful for patients. The anti-inflammatory effects of ketamine may be related to the suppression of TNF production by macrophage in the presence of bacteria. Propofol inhibits the phagocytosis and chemotaxis of human monocytes through GABAA receptors. Inhalational anesthetics, in a dose-dependent manner, suppress cytokine release, reduces lymphocyte proliferation, induce apoptosis of the lymphocytes, and inhibits the function of neutrophils. lnhalational anesthetics influence the endocrine response from the hypothalamus-pituitary-adrenal axis and indirectly through the secretions of hormones, such as glucocorticoids and catecholamines. Long-term administration of general anesthesia drugs, due to their effects on cytokines, can lead to disease progression in patients with immune deficiency.
________________________________________________
Anesthesia - ebook
Dalamagka, Maria
https://zenodo.org/records/14030341
https://www.researchgate.net/publication/382428764_ebookpdf
Anesthesiology articles
Dalamagka, Maria
https://zenodo.org/records/14030491
https://www.academia.edu/126273272/Anesthesiology_articles?source=swp_share
Maria Dalamagka | Semantic Scholar
https://share.google/yosXP2LLNBJSmCWOq
Dalamagka, Maria
2nd World Congress on Advances in Preventive Medicine and Public Health 2026. Vienna, Austria. "Multiple sclerosis an chronic demyelinating disease and anesthesia management" DOI: 10.13140/RG.2.2.14210.34245
Comments
Post a Comment