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Maria Dalamagka academic profile

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Multiple sclerosis an chronic demyelinating disease and anesthesia management

Maria I. Dalamagka 

Zenodo 
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 Academia.edu
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Review Article

Magna Scientia Advanced Research and Reviews, 2025, 15(01), 180-184
Article DOI: 10.30574/msarr.2025.15.1.0124


 

Abstract: 

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) and the most common chronic demyelinating disease affecting approximately 2.8 million people worldwide. Its high prevalence worldwide makes it probable for an anesthesia professional to take care of a patient diagnosed with MS at some point during their career. MS is an immune-mediated disease characterized by inflammation, demyelination, and axonal damage in the central nervous system. The course of MS is characterized by exacerbations and remissions at unpredictable intervals over a period of several years. Progression of disability due to MS is highly variable among patients. General, epidural, and spinal anesthesia are generally deemed safe when used in patients with the disease. General anesthesia is the most common anesthetic technique used. There is more controversy surrounding spinal anesthesia, but it seems spinal anesthesia can be administered safely without any additional increased risk of disease relapse. The purpose of the preoperative assessment is to ensure the patient undergoes a safe and adequate anaesthetic experience by selecting the most suitable type of anaesthesia. This assessment must include the full documentation of the neurological deficits detailed by the neurologist in charge of the patient. The use of an established score such as the “Expanded Disability Status Scale” score or “EDSS” score should also be used in order to evaluate the degree of disability. Besides neurological data, the preoperative assessment conducted by the anaesthesiologist should also document any respiratory, cardiac, renal, hepatic, autonomic or any other medical comorbidities. There is a lack of published guidelines on the management of patients with multiple sclerosis (MS) undergoing procedures that require anaesthesia. The anaesthetic management covers preoperative assessment, choice of anaesthetic techniques and agents, side-effects of drugs used during anaesthesia and their potential impact on the disease evolution and drug interactions. The choice of the anaesthetic technique used should be made after careful assessment of the risks and benefits for each specific patient and his preference must also be considered. The association of general anaesthesia and epidural with low concentrations of local anaesthetic are considered safe. Post-operative MS relapses are not affected by the choice of the anaesthetic technique, and that all techniques, including general anaesthesia, may be safely used.





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Autoimmune diseases in children and anesthesia

Maria I Dalamagka 


Semantic Scholar 
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ResearchGate 
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Review Article

Magna Scientia Advanced Biology and Pharmacy, 2025, 14(01), 045-052
Article DOI: 10.30574/msabp.2025.14.1.0022


 

Abstract: 

Autoimmune diseases in children may be linked to genetic, environmental, and hormonal factors. It’s estimated that 5% of children worldwide have at least one autoimmune condition, with many experiencing multiple autoimmune challenges. Around 80 autoimmune diseases are present. However, autoimmune diseases in children are rare. When they occur they can be challenging to diagnose and difficult to treat. Advances in our knowledge of the immune system are uncovering connections between inflammation and many different diseases. All autoimmune diseases have relapsing and remitting tendencies. Autoimmune diseases can affect almost any part of the body, though they often target connective tissues (skin, muscle and joints). Symptoms can range from fatigue and mild rashes to rare, serious side effects, like seizures. Diagnosis can be difficult, because many symptoms tend to come and go and are frequently nonspecific. They occur in different kinds of autoimmune diseases as well as other types of illnesses, like infection and cancer. Autoimmune diseases occur most often in females by a 3-to-1 margin over males. Organ-specific disorders (also called localized) focus on one organ or a specific type of tissue: Addison's disease affects the adrenal glands; Autoimmune hepatitis affects the liver; Crohn's disease affects the gastrointestinal tract; Multiple sclerosis (MS) affects the central nervous system; Type 1 diabetes affects the pancreas; Ulcerative colitis affects the gastrointestinal tract. Non-organ-specific disorders (also called systemic) cause problems throughout the body: Juvenile dermatomyositis affects the skin and muscles; Juvenile idiopathic arthritis affects the joints and sometimes the skin and lungs; Lupus affects the joints, skin, liver, kidneys, heart, brain, and other organs; Scleroderma affects the skin, joints, intestine, and sometimes the lungs. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are rare neurobehavioral disorders in children. Affected children may have a diverse array of perioperative manifestations including compulsive behavior, agitation, and abnormal movements. Intravenous anesthetics have anti-inflammatory properties, which in most septic cases are useful for patients. The anti-inflammatory effects of ketamine may be related to the suppression of TNF production by macrophage in the presence of bacteria. Propofol inhibits the phagocytosis and chemotaxis of human monocytes through GABAA receptors. Inhalational anesthetics, in a dose-dependent manner, suppress cytokine release, reduces lymphocyte proliferation, induce apoptosis of the lymphocytes, and inhibits the function of neutrophils. lnhalational anesthetics influence the endocrine response from the hypothalamus-pituitary-adrenal axis and indirectly through the secretions of hormones, such as glucocorticoids and catecholamines. Long-term administration of general anesthesia drugs, due to their effects on cytokines, can lead to disease progression in patients with immune deficiency.
 
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Anesthesia -  ebook
Dalamagka, Maria

https://zenodo.org/records/14030341

https://www.researchgate.net/publication/382428764_ebookpdf

Anesthesiology articles
Dalamagka, Maria

https://zenodo.org/records/14030491

https://www.academia.edu/126273272/Anesthesiology_articles?source=swp_share




Maria Dalamagka | Semantic Scholar

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Maria Dalamagka - Aristotle University of Thessaloniki https://share.google/MavrU9ih9SY2KJb1s



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Maria Dalamagka - Consensus https://share.google/2D4d6bb0bV1taAkM3



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https://auth.academia.edu/MariaDalamagka/CurriculumVitae



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Study Details | NCT01722253 | Postoperative Analgesia After Low Frequency Electroacupuncture | ClinicalTrials.gov https://share.google/EGGgo74ilo4p6i18A



http://ikee.lib.auth.gr.  PhD thesis Maria Dalamagka - ΜΑΡΙΑ ΔΑΛΑΜΑΓΚΑ

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University of Crete (UoC), Greece.   Library :

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Panteion University  of Social and Political Sciences.       Library & Information Center :

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University of the Aegean

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National and Kapodistrian University of Athens
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CSV https://doi.org/10.13140/RG.2.2.12204.94086


Publications. https://doi.org/10.13140/rg.2.2.13260.07043


Presentations: https://doi.org/10.13140/rg.2.2.22682.50885



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Dalamagka, Maria
2nd World Congress on Advances in Preventive Medicine and Public Health 2026.     Vienna,  Austria. "Multiple sclerosis an chronic demyelinating disease and anesthesia management" DOI: 10.13140/RG.2.2.14210.34245





2ⁿᵈ Edition of Pharma R&D and Drug Discovery World Conference 2026. Dalamagka, Maria "Epilepsy in children and anesthesia"

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The use of hypnosis as a tool for relieving pain | Addiction Medicine Conference | Psychiatry Conferences 2026 | Mental Health Conferences https://share.google/uerM8IlX0xBoLCI9U



Pediatric neurodegenerative disorders and anesthesia considerations | Neurology Conferences | Neuroscience Conferences | Neurology 2026 https://share.google/0hsKZ0fhn9lkUIy21



Multiple sclerosis an chronic demyelinating disease and anesthesia management https://share.google/Vz4uog8wpStGfmIoV



Committee | Global Meet & Expo on Vaccines Research and Development | Academy Nature https://share.google/mvlF3hvSNCjWzSl46



Speakers | 2nd International Summit on Surgery and Anesthesia | Spectrum Conferences https://share.google/Ts4pAXnEWmkHBWoc9



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Speakers | 8th Edition of the Largest European Meet & Exhibition on Neurology and Brain Disorders | Rigel International https://share.google/0kR0ZM9SKPzLpQyvE



Systematic Review: Acupuncture in Chronic Pain, Low Back Pai | 60183 https://share.google/1LyokUoHvsvdoHIaB



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Pathology associated with kidney failure and anesthesia - R Discovery https://share.google/jVzU0vW7CR03w56sA


Journal articles: 'Combined spinal-epidural anesthesia' – Grafiati https://share.google/2Ve5qhoojPFs2bYaF


Health Treatment Methods - Consensus Academic Search Engine https://share.google/yuiAUijyYeFXFF7jo



What are the long-term effects of electronic acupuncture devices on chronic low back pain? - Consensus https://share.google/tnYmSr6SU70Orpxeh



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Effectiveness of acupuncture vs. electroacupuncture for chronic low back pain - Consensus https://share.google/3kyp7ZYLNki5GOTOF


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Newer Agents for Rapid Sequence Intubation: Etomidate and Rocuronium | Semantic Scholar https://share.google/SCWqjU4Psfe8JYUfo



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penile-erection-during-remifentanil-anesthesia-in-children - Ask this paper | Bohrium https://share.google/8XD5nXpVYx1EqS2ML


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MARIA DALAMAGKA MD, MSc, PhD   Aristotle University of Thessaloniki (AUTH - Greece)  Anaesthetist - Physician, acupuncturist Related  Queen Mary University of London Sohag University, Egypt UKSH ( Universitätsklinikum Schleswig-Holstein) Author Academy AIREC UAEM Autonomous University of the State of Mexico.   UAEM Profile available:   https://www.redalyc.org/autor.oa?id=75729 https://orcid.org/0000-0001-8703-8770 University of Crete (UoC), Greece.   Library : https://share.google/KjCMXfqjUCwrxC9Wm association of Greek academics Panteion University  of Social and Political Sciences.       Library & Information Center : https://share.google/aOnoZaxulyrX9Kpu8 Maria Dalamagka academic profile https://share.google/3jZOfBHvdnk5CHBOJ ‪Maria Dalamagka‬ - ‪ Google Scholar ‬  https://share.google/T4toRXqNT05TkN1Vy  https://share.google/GrSS0sx7suKWNgreL University of the Aegean https://share.google/tH6tov9GdYLzWZ...
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